Cydekin 100mg Capsule contains Palbociclib, is used, usually in combination with hormonal anticancer therapy, to treat certain forms of breast cancer (HER2-negative, estrogen receptor-positive) that have metastasized to other organs. For best results, take it with food at the same time every day. 

Brand Name: Cydekin

Composition: Palbociclib

Mechanism of Action:

Palbociclib inhibit the CDK4 and CDK6, which are essential for controlling the cell cycle. Palbociclib inhibits the growth of cancer cells by blocking these kinases, which stops cells from moving from the G1 phase of the cell cycle to the S phase.

Uses: 

• Hormone receptor-positive breast cancer.
• Advanced or metastasized breast cancer.

Side effects:

• Neutropenia (low white blood cell count)
• Fatigue
• Nausea
• Vomiting
• Fever
• Diarrhea
• Mouth sores
• Severe infections due to low neutrophil counts
• Liver enzyme elevations

Dosage and Administration: 

To improve absorption, Palbociclib should be taken with meals. Instead of chewing or crushing the pills, they should be consumed whole. Palbociclib is normally given orally once day for 21 days at a dose of 100mg, with a 7-day break (28-day cycle).

Safety Advise:

Lungs  

The safety of Cydekin for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Cydekin for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Cydekin for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Cydekin should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Cydekin while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Storage:

Keep at room temperature, between 20°C and 25°C. Steer clear of extreme humidity or heat. The capsules should be kept out of direct sunlight in their original packaging.

How to use this Medication?

Drink a glass of water along with this medication. Observe the medicine label's instructions. This drug should be taken with meals. Take this prescription in the morning if you take it once daily. Avoid taking it more frequently than prescribed. Avoid stopping your prescription abruptly as this might trigger a serious response.

The amount of medicine you should take will be determined by your care team. To prevent any negative effects, your care team may gradually reduce the dosage if they decide you should stop taking the drug.

Contact an emergency department or poison control center right away if you believe you may have taken too much of this medication.

References:

1.      Dhillon S. Palbociclib: first global approval. Drugs. 2015 Apr;75:543-51.

2.      Cadoo KA, Gucalp A, Traina TA. Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. Breast Cancer: Targets and Therapy. 2014 Aug 4:123-33.

3.      Turner NC, Ro J, André F, Loi S, Verma S, Iwata H, Harbeck N, Loibl S, Huang Bartlett C, Zhang K, Giorgetti C. Palbociclib in hormone-receptor–positive advanced breast cancer. New England Journal of Medicine. 2015 Jul 16;373(3):209-19.

4.      Serra F, Lapidari P, Quaquarini E, Tagliaferri B, Sottotetti F, Palumbo R. Palbociclib in metastatic breast cancer: current evidence and real-life data. Drugs in Context. 2019 Jul 16;8:212579.

Disclaimer:

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Marketer Details:

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Country of origin: India