Oxitoz 50mg Injection

Oxitoz 50mg Injection contains Oxaliplatin as its active ingredient. The chemotherapy drug that is mainly used to treat colorectal cancer is oxaliplatin. It is one of the group of medications called platinum-based antineoplastic medicines.

Brand Name: Oxitoz

Composition: Oxaliplatin 50mg

Mechanism of Action:

Following its metabolism in the body, oxaliplatin produces reactive platinum molecules. These substances attach themselves to DNA and cause DNA strands to cross-link, which prevents cancer cells from replicating and transcriptionally using DNA. This eventually results in apoptosis, or cell death, especially in malignant cells that divide quickly. Oxaliplatin is effective against some cancer cells that are resistant to other medicines like cisplatin and carboplatin, but it has a different toxicity profile than other platinum-based medications.

Uses:

• Colorectal Cancer

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Rash

·       Headache

·       Weakness

·       Fever

·       Difficulty breathing

·       Allergic reactions

·       Mouth sores

·       Constipation

Contraindications/Warnings: 

Oxaliplatin has several important, well-established warnings:

(1) Peripheral sensory neuropathy very common and dose-limiting; it is characteristically triggered or worsened by exposure to cold, so patients should be advised to avoid cold drinks, ice, and touching cold objects for several days after each infusion

(2) Anaphylactic-like reactions hypersensitivity reactions, including anaphylaxis, can occur during or shortly after infusion

(3) Hepatotoxicity hepatic sinusoidal obstruction syndrome (veno-occlusive disease) has been reported

(4) Pulmonary fibrosis/interstitial lung disease rare but potentially fatal (see the "Difficulty breathing" side effect listed below)

(5) Rare cases of hemolytic uremic syndrome

(6) Myelosuppression. Contraindicated in patients with known hypersensitivity to oxaliplatin or other platinum compounds, pre-existing severe peripheral neuropathy, and in pregnancy/breastfeeding.

Safety Advise:

Kidney  

Dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease, as oxalipatin can cause elevated liver enzymes. Kindly speak with your healthcare provider.

Lungs 

Oxaliplatin has been associated with rare but potentially fatal pulmonary fibrosis/interstitial lung disease; report any new or worsening cough or breathlessness to your healthcare provider promptly.

Pregnancy  

Use oxalipatin during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Alcohol  

The safety of using Oxitoz 50mg Injection with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store in a refrigerator (2-8°C). Protect from light. Do not freeze.

How to use this medication?

Oxaliplatin is a liquid solution that is administered intravenously. A physician or nurse administers oxaliplatin. Typically, it is administered once every 14 days.

Request a copy of the manufacturer's information for the patient from your physician or pharmacist.

References:

1. Raymond E, Chaney SG, Taamma A, Cvitkovic E. Oxaliplatin: a review of preclinical and clinical studies. Annals of Oncology. 1998 Oct 1;9(10):1053-71.

2. Graham J, Muhsin M, Kirkpatrick P. Oxaliplatin. Nature reviews Drug discovery. 2004 Jan;3(1):11-2.

3. Raymond E, Faivre S, Chaney S, Woynarowski J, Cvitkovic E. Cellular and molecular pharmacology of oxaliplatin. Molecular cancer therapeutics. 2002 Jan 1;1(3):227-35.

4. Misset JL, Bleiberg H, Sutherland W, Bekradda M, Cvitkovic E. Oxaliplatin clinical activity: a review. Critical reviews in oncology/hematology. 2000 Aug 1;35(2):75-93.

Disclaimer:

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Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Country of origin: India