Genotropin 36IU Injection (12mg/ml) contains Somatropin, a recombinant human growth hormone (rHGH). It is primarily used to treat growth hormone deficiency in both children and adults, as well as other growth-related disorders.

Brand Name: Genotropin

Composition: Somatropin

Mechanism of Action:

It stimulates growth and controls metabolism by imitating the action of natural human growth hormone (GH), which is derived from somatropin. It binds to growth hormone (GH) receptors on target cells, particularly in the liver, to stimulate the synthesis of Insulin-like Growth Factor 1 (IGF-1), an essential protein for the development of bone and muscle. Somatropin decreases insulin sensitivity to increase protein synthesis, facilitate fat breakdown, and control glucose metabolism. It helps with tissue regeneration and repair as well as children's linear bone growth. Taken together, these activities help children and adults grow, build muscle, and have healthy metabolisms.

Uses:

• Growth Hormone Deficiency in children and adults.
• Short Stature due to Turner syndrome or chronic renal insufficiency in children.
• Wasting Syndrome in HIV patients.
• Prader-Willi Syndrome: To improve growth and body composition in children with this genetic disorder.

Dosage and Administration:

In pediatric patients, the dose is individualized based on the patient’s weight and medical condition whereas in adults the dosage is adjusted based on tolerance and clinical response. Administered via subcutaneous injection, usually daily at bedtime.

Side Effects:

• Injection site reactions
• Headaches
• Muscle or joint pain
• Swelling
• Hyperglycemia
• Hypothyroidism

Safety Advise: 

Kidney  

 The usage of Genotropin injection in individuals with kidney disease is not well-understood. Kindly speak with your physician.

Liver    

The usage of Genotropin injection in individuals with liver disease is not well-understood. Kindly speak with your physician.

Pregnancy  

Consult a healthcare provider if you are pregnant as somatropin's safety during these period is unclear.

Breast Feeding   

Consult a healthcare provider if you are breastfeeding, as somatropin's safety during these period is unclear.

Storage:

Store in the refrigerator at 2°C - 8°C. Do not freeze and keep the vial away from light.

References:

1.     Mehta A, Hindmarsh PC. The use of somatropin (recombinant growth hormone) in children of short stature. Pediatric Drugs. 2002 Jan;4:37-47.

2.     Svensson J, Johannson G. Long-term efficacy and safety of somatropin for adult growth hormone deficiency. Treatments in Endocrinology. 2003 Apr;2:109-20.

3.     Pawlikowska-Haddal A. Growth hormone therapy with norditropin (somatropin) in growth hormone deficiency. Expert opinion on biological therapy. 2013 Jun 1;13(6):927-32.

4.     van Dam PS. Somatropin therapy and cognitive function in adults with growth hormone deficiency: a critical review. Treatments in Endocrinology. 2006 Jun;5(3):159-70.

How to use this Medication?

For growth hormone replacement therapy or associated diseases, somatropin injections are subcutaneously injected and come in prefilled pens or vials. They are typically given once a day. Depending on the treatment, the frequency may change; for example, daily or every other day for HIV-associated wasting syndrome or daily for short bowel syndrome.

The initial somatropin injection may be given by your doctor, or they may instruct you or a caregiver on how to give one at home. Ensure you understand the instructions and ask your healthcare provider any questions about injection locations, needle disposal, or administration.

Injection somatropin should be continued even if you feel good. Avoid stopping somatropin injection without first seeing your physician.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

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