Siromus 1mg Tablet contains Sirolimus, which is an immunosuppressive drug used primarily to prevent organ rejection in transplant patients and to treat certain conditions related to the immune system.

Brand Name: Siromus

Composition: Sirolimus

Mechanism of Action:

By inhibiting the function of the mammalian target of rapamycin (mTOR), a crucial regulator of cell growth and metabolism, sirolimus prevents T-lymphocytes from activating and proliferating in response to antigenic and cytokine stimulation.

Uses:

Organ Transplant

Dosage and Administration:

For kidney transplants, a maintenance dose of 2 mg once daily may be administered after an initial loading dose, typically 6 mg, on the day of the transplant. Oral Siromus tablets can be taken with or without meals. When it comes to meals, consistency is crucial.

 Side Effects:

• Headache
• Nausea
• Fever
• Vomiting
• Joint Pain
• Abdominal pain
• Constipation
• Chills
• Cough
• High Blood Pressure
• Dizziness
• Weight Loss
• Insomnia

Safety Advise:

Liver  

Patients with liver illness should use Siromus with caution. Siromus dosage adjustments might be required. Kindly speak with your healthcare provider.

Kidney  

Patients with renal illness should use Siromus with caution. Siromus dosage adjustments might be required. Kindly speak with your healthcare provider.

Pregnancy  

Animal studies suggest that Siromus could be harmful to the fetus, so it may not be safe to use during pregnancy. Before using it, discuss benefits and risks with your healthcare provider.

Breast Feeding  

Using Siromus while nursing is most likely dangerous. The medication may damage the developing baby if it enters the breastmilk, according to limited human data. Kindly speak with your healthcare provider.

Alcohol  

It is unknown if drinking alcohol while using Siromus is unsafe. Kindly speak with your healthcare provider.

Storage:

Store at room temperature (20-25°C or 68-77°F) in a tightly closed container, away from light and moisture

How to use this Medication?

As prescribed, take this medication orally at the same time each day, right after waking up, and with no more than four ounces of plain water. After ingesting the tablets whole, wait at least half an hour before eating, drinking, or taking any other drugs.

With every prescription and refill, the pharmacist will provide you with a unique MedGuide. Every time, make sure to carefully read this information.

 

Discuss the usage of this drug in children with your care team. Extra caution could be required.

References:

1.    Sehgal SN. Sirolimus: its discovery, biological properties, and mechanism of action. InTransplantation proceedings 2003 May 1 (Vol. 35, No. 3, pp. S7-S14).  Elsevier.

2.      Stallone G, Infante B, Grandaliano G, Gesualdo L. Management of side effects of sirolimus therapy. Transplantation. 2009 Apr 27;87(8S):S23-6.

3.      Stenton SB, Partovi N, Ensom MH. Sirolimus: the evidence for clinical pharmacokinetic monitoring. Clinical pharmacokinetics. 2005 Aug;44:769-86.

4.      Mahalati K, Kahan BD. Clinical pharmacokinetics of sirolimus. Clinical pharmacokinetics. 2001 Aug;40:573-85.

Disclaimer:

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Marketer details

Name: Zydus Life Sciences

Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.

Country of origin: India