Lobet 100mg Tablet contains Labetalol, a medication used to treat high blood pressure (hypertension), such as in pregnancy-induced hypertension and hypertensive emergencies. By lowering heart rate and relaxing blood vessels, it works as an alpha-blocker and beta-blocker to help reduce blood pressure.

Brand Name: Lobet

Composition: Labetalol

Mechanism of Action:

Labetalol inhibits alpha-1 adrenergic receptors, which results in vasodilation and a reduction in peripheral resistance, as well as beta-adrenergic receptors (β1 and β2), which lower heart rate and myocardial contractility. Without producing reflex tachycardia, this dual action effectively lowers blood pressure.

Uses:

·       Hypertension

·       Pregnancy-induced hypertension

·       Angina

Dosage and Administration:

Labetalol is typically taken twice day at a dose of 100 mg; however, depending on the patient's reaction, this dosage may be progressively raised. As prescribed by the doctor, the pill should be taken orally with or without food, and the maintenance dose usually falls between 200 and 400 mg twice a day.

Side Effects:

·       Dizziness

·       Fatigue

·       Headache

·       Nausea

·       Postural hypotension

·       Nasal congestion

·       Bradycardia

·       Heart block

·       Hepatotoxicity

·       Bronchospasm

Safety Advise:

Lungs  

The safety of Lobet tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Lobet tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Lobet tablet for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Lobet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Lobet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep between 15°C and 30°C at room temperature. Stay away from humidity and light.

How to use this Medication? 

Labetalol is available as an oral tablet. Typically, two or three doses are given daily. Take labetalol at roughly the same times each day to help you remember to take it. Pay close attention to the instructions on your prescription label, and ask your pharmacist or doctor to clarify any parts you don't understand. Follow the directions on labetalol properly. Never take more or less of it, or take it more frequently than your doctor has suggested.

To give your body time to get used to the drug, your doctor can start you on a low dose of labetalol and then gradually raise it. Discuss your feelings and any symptoms you are experiencing during this period with your physician.

References:

1.      MacCarthy EP, Bloomfield SS. Labetalol: a review of its pharmacology, pharmacokinetics, clinical uses and adverse effects. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1983 Jul 8;3(4):193-217.

2.      Abdullah A, Yusof MK. Labetalol: a brief current review. Pharmacophore. 2019;10(6-2019):50-6.

3.      Brogden RN, Heel RC, Speight TM, Avery GS. Labetalol: a review of its pharmacology and therapeutic use in hypertension. Drugs. 1978 Apr;15:251-70.

Disclaimer:

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Marketer details

Name: Samarth Life Sciences Pvt Ltd

Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Country of origin: India