Pomalid 4mg Capsule contains Pomalidomide, an immunomodulatory drug primarily used to treat multiple myeloma, a type of blood cancer. It is usually administered to individuals whose disease has advanced after they have received treatment with other medications, such as proteasome inhibitors and lenalidomide.

Brand Name: Pomalid

Composition: Pomalidomide

Mechanism of Action:

Pomalidomide's intricate mechanism includes both immune system activation and direct anti-cancer actions. It boosts the body's immunological response against cancer cells by activating T-cells and natural killer cells. By blocking important signaling pathways that encourage the growth of cancer cells, it also prevents multiple myeloma cells from proliferating and triggers apoptosis. It also prevents angiogenesis, which lowers the tumor's blood supply, which is essential for its growth.

Uses:

Multiple Myeloma

Dosage and Administration:

Pomalid 4mg the dosage of capsules can be changed according to renal function, adverse effects, and patient tolerance. Do not chew, break, or open the capsules; instead, consume them whole with water.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Rash

·       Headache

·       Weakness

·       Fever

·       Anemia

·       Neutropenia

·       Difficulty breathing

·       Allergic reactions

·       Mouth sores

·       Constipation

Safety Advise:

Kidney  

Dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease, as paclitaxel can cause elevated liver enzymes. Kindly speak with your healthcare provider.

Pregnancy  

Use pomalidomide during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Alcohol  

The safety of using Pomalid 4mg capsule with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature (below 25°C), protected from light and moisture. Keep out of reach of children.

How to use this medication?

As prescribed by your physician, take this medication orally, with or without food, once day for 21 days, followed by a 7-day break. This is a single therapy cycle. Continue taking the medication as prescribed by your physician.

Using water, swallow the capsules whole. The capsules should not be opened, broken, crushed, chewed, or handled more than necessary. Wash the affected region with soap and water if any of the capsule's powder gets on your skin.

References:

1.      Lacy MQ, McCurdy AR. Pomalidomide. Blood, The Journal of the American Society of Hematology. 2013 Oct 3;122(14):2305-9.

2.      Engelhardt M, Wäsch R, Reinhardt H, Kleber M. Pomalidomide. Small molecules in oncology. 2014 Apr 23:359-72.

3.   Chanan-Khan AA, Swaika A, Paulus A, Kumar SK, Mikhael JR, Rajkumar SV, Dispenzieri A, Lacy MQ. Pomalidomide: the new immunomodulatory agent for the treatment of multiple myeloma. Blood cancer journal. 2013 Sep;3(9):e143-.

4.    Zhu YX, Kortuem KM, Stewart AK. Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leukemia & lymphoma. 2013 Apr 1;54(4):683-7.

Disclaimer:

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Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India