Nykron Tablet CombiPack contains two active ingredients: Netupitant (300 mg) and Palonosetron (0.5 mg). The main purpose of this combination is to avoid chemotherapy-related nausea and vomiting.

Brand Name: Nykron

Composition: Netupitant, Palonosetron

Mechanism of Action:

An antagonist of the neurokinin-1 (NK1) receptor, netupitant prevents substance P, a neurotransmitter implicated in vomiting, from working. It successfully avoids delayed nausea and vomiting, which usually happen more than 24 hours following chemotherapy, by blocking NK1 receptors in the brain. Conversely, palonosetron functions as a 5-HT3 receptor antagonist by inhibiting serotonin (5-HT3) receptors in the gastrointestinal system and brain. This relieves acute nausea and vomiting that happen within the first 24 hours following chemotherapy by blocking the vomiting center's activity. Nykron provides longer-lasting protection against nausea and vomiting by combining these two processes, which improves chemotherapy treatment tolerance.

Uses:

Chemotherapy Induced Nausea and Vomiting

Dosage and Administration:

Usually, a single dose of Nykron is given about an hour before to the commencement of chemotherapy. It's critical to adhere to the precise timing and dosage recommendations provided by your healthcare practitioner.

Side Effects:

·       Headache​

·       Constipation​

·       Fatigue​

·       Skin redness​

·       Upset stomach​

Safety Advise:

Lungs  

The safety of Nykron tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Nykron tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Nykron tablet for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Nykron tablet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Nykron tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep out of direct sunlight and moisture, and store below 30°C. Keep it out of children's reach.

References:

1.   Reddy S, Kumar SB, Venkatesh T, Punukollu UK, Sharma SB, Tripathi R, Bondili SK, Punukollu UK, Bharat S. Dexamethasone-Sparing Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting in Highly and Moderately Emetogenic Chemotherapy: The SHEILD Study. Cureus. 2024 Sep 26;16(9).

2.     Yang LP, Scott LJ. Palonosetron: in the prevention of nausea and vomiting. Drugs. 2009 Nov;69:2257-78.

3.     Aapro MS. Palonosetron as an anti-emetic and anti-nausea agent in oncology. Therapeutics and clinical risk management. 2007 Dec 30;3(6):1009-20.

Disclaimer:

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Marketer details

Name: Zydus Cadila

Address: Zydus Tower, Satellite Cross Roads, Ahmedabad – 380015 Gujarat, India.

Country of origin: India