Mikastar 500mg Injection – Uses, Price & Amikacin for Bacterial Infections

Mikastar 500mg Injection contains Amikacin is a member of the aminoglycoside class of antibiotics. Serious bacterial infections, particularly those brought on by Gram-negative bacteria, are its main use.

Brand Name: Mikastar

Composition: Amikacin

Mechanism of Action:

The active component of Mikastar 500mg Injection, amikacin, works by preventing the formation of bacterial proteins. It attaches itself to the bacterial 30S ribosomal subunit, preventing the synthesis of vital proteins and ultimately causing bacterial cell death. It works well against a wide variety of germs because of its bactericidal action.

Uses of Mikastar 500mg Injection:

Bacterial Infection

Dosage and Administration:

This Injection is administered by doctors or nurses either intravenously or intramuscularly. Age, weight, renal function, and the severity of the infection all affect dosage.

Side Effects:

·        Injection site reactions (pain, swelling, redness)

·        Nausea or vomiting

·        Diarrhoea

·        Skin rashes

·        Hearing loss

·        Nephrotoxicity

Contraindications/Warnings: 

Hypersensitivity to aminoglycosides, caution with neuromuscular blockade risk (especially with anesthetics or muscle relaxants, or in myasthenia gravis), and avoid co-administration with other nephrotoxic or ototoxic drugs (e.g., other aminoglycosides, loop diuretics, vancomycin) where possible.

Safety Advise:

Lungs  

The safety of Mikastar Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

Amikacin has a  risk of nephrotoxicity, usually reversible. Renal function and, ideally, serum drug levels should be monitored during treatment given its narrow therapeutic index. Kindly speak with your healthcare provider.

Kidney  

The safety of Mikastar Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Mikastar should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Mikastar while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep the temperature at less than 25°C. Avoid freezing. Keep out of children's reach.

How to use this Medication?

Every eight or twelve hours (two or three times a day), amikacin injection is administered as a liquid intravenously (into a vein) or intramuscularly (into a muscle). Amikacin is typically infused (given gradually) over 30 to 60 minutes when administered intravenously. The sort of infection you have determines how long your therapy will last.

Amikacin can be injected into your body in a hospital or administered at home. Your healthcare practitioner will demonstrate how to utilize amikacin injection if you will be receiving it at home. Make sure you comprehend these instructions, and if you have any concerns, consult your healthcare practitioner.

Frequently Asked Questions (FAQs):

1. What is Mikastar 500mg Injection used for?

It is used to treat selected serious bacterial infections, particularly susceptible Gram-negative infections.

2. How does Mikastar work?

Amikacin blocks bacterial protein synthesis, helping kill susceptible bacteria.

3. Is Mikastar an antibiotic?

Yes. Mikastar is an aminoglycoside antibiotic.

4. How is Mikastar administered?

It is administered by intravenous or intramuscular injection under medical supervision.

5. What are the common side effects?

Possible effects include injection-site reactions, nausea and changes in kidney or hearing function.

6. Does Mikastar require kidney monitoring?

Yes. Kidney function and sometimes Amikacin blood levels may require monitoring during treatment.

References:

1.      Ramirez MS, Tolmasky ME. Amikacin: uses, resistance, and prospects for inhibition. Molecules. 2017 Dec 19;22(12):2267.

2.      Kawaguchi H. Discovery, chemistry, and activity of amikacin. Journal of Infectious Diseases. 1976 Nov 1;134(Supplement_2): S242-8.

3.      Black RE, Lau WK, Weinstein RJ, Young LS, Hewitt WL. Ototoxicity of amikacin. Antimicrobial agents and chemotherapy. 1976 Jun;9(6):956-61.

4.      Bodey GP, Valdivieso M, Feld R, Rodriguez V. Pharmacology of amikacin in humans. Antimicrobial agents and chemotherapy. 1974 May;5(5):508-12.

Disclaimer:

The main goal of Apothecare Specialities Pvt Ltd is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Specialities Pvt Ltd, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Mankind Pharma Ltd
Address: 208, Okhla Industrial Estate, Phase III, New Delhi - 110020
Country of origin: India