Spegra Tablet – Uses, Price, Dosage & HIV Treatment Benefits

Spegra Tablet is a combination antiretroviral medication used for the treatment of HIV (Human Immunodeficiency Virus) infection. Dolutegravir, Emtricitabine, and Tenofovir Alafenamide are its three active ingredients; they all perform together to inhibit viral replication and boost immunity.

Brand Name: Spegra

Composition: Dolutegravir, Emtricitabine, and Tenofovir Alafenamide

Mechanism of Action:

Dolutegravir: Prevents the integration of viral DNA into the host genome, which is essential for the virus's replication, by inhibiting the integrase enzyme.
Emtricitabine: Prevents viral RNA from being converted to DNA by inhibiting the reverse transcriptase enzyme. Like emtricitabine, tenofovir alafenamide works against HIV by blocking the virus's ability to replicate by inhibiting reverse transcriptase.

Uses of Spegra Tablet:

HIV Infection

Dosage and Administration:

One tablet taken once a day, with or without food, is the usual dosage.

Side Effects of Spegra Tablet:

• Fatigue
• Headache
• Nausea
• Vomiting
• Fever
• Cough
• Insomnia
• Liver Function Abnormalities
• Allergic Reactions

Safety Advise:

Kidney  

Monitor kidney function regularly, as spegra can cause nephrotoxicity. Kindly speak with your healthcare provider.

Liver  

Monitor liver function regularly, as spegra can cause liver impairement. Kindly speak with your healthcare provider.

Pregnancy  

Spegra should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using spegra while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Spegra should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Store Spegra Tablet at a temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in the original packaging to protect them from light and moisture. Keep out of reach of children.

References:

1.    Sax PE, Pozniak A, Montes ML, Koenig E, DeJesus E, Stellbrink HJ, Antinori A, Workowski K, Slim J, Reynes J, Garner W. Coformulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection (GS-US-380–1490): a randomised, double-blind, multicentre, phase 3, non-inferiority trial. The Lancet. 2017 Nov 4;390(10107):2073-82.

2.   Venter WD, Sokhela S, Simmons B, Moorhouse M, Fairlie L, Mashabane N, Serenata C, Akpomiemie G, Masenya M, Qavi A, Chandiwana N. Dolutegravir with emtricitabine and tenofovir alafenamide or tenofovir disoproxil fumarate versus efavirenz, emtricitabine, and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection (ADVANCE): week 96 results from a randomised, phase 3, non-inferiority trial. The lancet HIV. 2020 Oct 1;7(10):e666-76.

Frequently Asked Questions (FAQs):

1. What is Spegra Tablet?

Spegra is a combination antiretroviral medication containing Dolutegravir, Emtricitabine, and Tenofovir Alafenamide. It may be prescribed for the management of HIV infection. Strict adherence to an infectious disease specialist's oversight is required.

2. How may Spegra work?

It is believed to inhibit specific viral enzymes, which may potentially prevent the HIV virus from multiplying and help reduce the viral load in the body.

3. What conditions may it be prescribed for?

It is considered for the treatment of HIV-1 infection in adults and adolescents, based on viral load testing ordered by a doctor.

4. How is it administered?

It is typically taken orally as one tablet once daily. Adhering strictly to a consistent daily schedule is crucial to potentially prevent drug resistance.

5. Can it be taken with food?

It may generally be taken with or without food. You must adhere to the dietary intake advice provided by your healthcare provider.

6. What are the possible side effects?

Patients may potentially experience headache, nausea, diarrhoea, or insomnia. Discuss any ongoing side effects with your physician.

7. Does it cure HIV?

It is not a cure; it may potentially help suppress the virus. Lifelong adherence to the medication is typically required to maintain viral suppression.

8. Are there bone or kidney risks?

While Tenofovir Alafenamide is designed to have potentially less impact on bones and kidneys, adherence to regular monitoring by your doctor remains essential.

9. Can I stop taking it abruptly?

Stopping the medication without a doctor's approval may potentially lead to a rapid increase in viral load and resistance. Adhere strictly to your doctor's protocols.

10. Does it prevent transmission?

While reducing viral load may potentially reduce transmission risk, you must adhere to safe practices to protect others as advised by your physician.

11. Are there drug interactions?

Yes, it may potentially interact with antacids, iron supplements, and other medications. You must inform your doctor of all medicines you take to ensure safe prescribing.

12. Is Spegra a prescription medicine?

Yes, it is a prescription-only antiretroviral medication.

Medical Disclaimer:

Spegra Tablet is a prescription-only medicine and must be used strictly under the supervision and guidance of a qualified healthcare professional. Do not self-medicate, alter the dosage, or discontinue use without consulting your doctor. The information provided here is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Individual results, benefits, and risks may vary. Always consult your physician before starting, changing, or stopping any medication.

Marketer details

Name: Emcure Pharmaceuticals Ltd

Address: 255/2, Hinjawadi, Pune - 411057, India

Country of origin: India

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