Defrijet 500mg Tablet contains Deferasirox, an oral iron chelator used to treat chronic iron overload triggered by blood transfusions, such as in conditions like thalassemia, sickle cell anemia, or other chronic anemias requiring frequent transfusions. It aids in the removal of extra iron from the body, which under such circumstances can build up to dangerous amounts.

Brand Name: Defrijet

Composition: Deferasirox

Mechanism of Action:

A selective iron chelator called deferasirox attaches itself to extra iron in the blood and creates a complex that the body can eliminate through stool. It helps avoid iron poisoning and damage to organs, including the liver, heart, and endocrine glands, by lowering excess iron.

Uses:

• Chronic Iron Overload
• Non-Transfusion-Dependent Thalassemia Syndromes

Dosage and Administration:

Depending on the patient's reaction and the degree of iron overload as assessed by blood ferritin levels, the dosage may be changed. At least half an hour before eating, defrijet should be taken without food and swallowed whole with water.

Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Constipation
• Itching
• Abdominal pain
• Skin rash
• Increased serum creatinine
• Elevated liver enzymes

Safety Advise:

Kidney  

Regular kidney function tests (serum creatinine) should be performed on patients on deferasirox in order to check for toxicity. Kindly speak with your healthcare provider.

Liver  

Regular liver function tests should be performed on patients on deferasirox in order to check for toxicity. Kindly speak with your healthcare provider.

Pregnancy  

Deferasirox's safety during pregnancy is unknown, hence it should only be taken when absolutely necessary. Kindly speak with your healthcare provider.

Breast Feeding  

Deferasirox's safety during breastfeeding is unknown, hence it should only be taken when absolutely necessary. Kindly speak with your healthcare provider.

Alcohol  

The safety of drinking alcohol while taking Defrijet 500 Tablets is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature, typically between 15°C and 30°C (59°F and 86°F). Keep in a dry place, protected from light and moisture.

How to use this Medication?

Take this medication orally. Observe the medicine label's instructions. Take this medication at least 30 minutes before or two hours after eating, on an empty stomach. Avoid taking it with food. Take your medication on a regular basis. Avoid taking it more frequently than prescribed. Except as directed by your physician, do not discontinue taking.

Consult your pediatrician about this medication's use in kids. Precautions do need to be taken, even though this medication may be recommended for certain diseases in children as young as two years old.

References:

1.     Dou H, Qin Y, Chen G, Zhao Y. Effectiveness and safety of deferasirox in thalassemia with iron overload: a meta-analysis. Acta haematologica. 2019 Nov 30;141(1):32-42.

2.     Vichinsky E. Clinical application of deferasirox: practical patient management. American journal of hematology. 2008 May;83(5):398-402.

3.     Stumpf JL. Deferasirox. American Journal of Health-System Pharmacy. 2007 Mar 15;64(6):606-16.

4.   Chirnomas D, Smith AL, Braunstein J, Finkelstein Y, Pereira L, Bergmann AK, Grant FD, Paley C, Shannon M, Neufeld EJ. Deferasirox pharmacokinetics in patients with adequate versus inadequate response. Blood, The Journal of the American Society of Hematology. 2009 Nov 5;114(19):4009-13.

Disclaimer:

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Marketer details

Name: Sun Pharmaceutical Industries Ltd

Address: Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Country of origin: India