S-One Trio 20mg Capsules containing the active constituents Tegafur, Gimeracil, and Oteracil are used as anticancer drugs, particularly in the treatment of certain types of cancers such as gastric, colorectal, and other solid tumors. 

Brand Name: S-one Trio

Composition: Tegafur, Gimeracil, Oteracil

Mechanism of Action:

Tegafur is metabolized into 5-FU in the body, which inhibits thymidylate synthase, an enzyme essential for DNA synthesis in cancer cells, leading to cell death. Gimeracil enhances the anticancer effects of 5-FU by preventing its rapid degradation, allowing for prolonged exposure of cancer cells to the active drug. Oteracil protects normal tissues, especially the gastrointestinal tract, from the toxic effects of 5-FU, minimizing side effects like severe diarrhea and mucositis.

Uses:

• Gastric Cancer
• Colorectal Cancer

Dosage and Administration:

Administered orally, usually in cycles as per oncologist recommendations, which vary based on cancer type, stage, and patient tolerance.

Side Effect:

• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Fatigue
• Stomatitis (mouth sores)
• Hand-foot syndrome
• Cardiotoxicity
• Liver enzyme elevation

Safety Advises:

  Liver  

Periodic tests for liver function are recommended as the drug can cause toxicity, especially in patients with pre-existing conditions. Kindly speak with your healthcare provider.

Kidney  

Periodic tests for kidney function are recommended as the drug can cause toxicity, especially in patients with pre-existing conditions. Kindly speak with your healthcare provider.

Pregnancy  

S-one Trio is contraindicated in pregnancy due to the risk of fetal harm. Kindly speak with your healthcare provider.

Breast Feeding  

Breastfeeding should be avoided, as the drug can be excreted in breast milk. Kindly speak with your healthcare provider.

Storage:

Store in a cool environment with temperatures between 20°C and 25°C (68°F to 77°F). Protect from moisture, heat, and light. Do not freeze. Keep the medication in its original packaging until ready for use.

References:

1.  Tegafur, Gimeracil and Oteracil Capsules [Package Insert]. Torrent Pharmaceuticals Ltd.; 2022.

2.  Kobayakawa M, Kojima Y. Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies. OncoTargets and therapy. 2011 Nov 15:193-201.

3.  Kinoshita T, Nashimoto A, Yamamura Y, Okamura T, Sasako M, Sakamoto J, Kojima H, Hiratsuka M, Arai K, Sairenji M, Fukushima N. Feasibility study of adjuvant chemotherapy with S-1 (TS-1; tegafur, gimeracil, oteracil potassium) for gastric cancer. Gastric Cancer. 2004 Jun;7:104-9.

4.   Sakagashira M. Gimeracil/oteracil/tegafur. Reactions. 2014 Dec;1531:97-13.

Disclaimer:

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Marketer details

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Country of origin: India