Geftinat 250mg Tablet contains Gefitinib, which is an oral medication used primarily in the treatment of non-small cell lung cancer that has specific mutations in the epidermal growth factor receptor gene. As a tyrosine kinase inhibitor, gefitinib functions by obstructing the signals that encourage the development of cancer cells.

Brand Name: Geftinat

Composition: Gefitinib

Mechanism of Action:

The signaling pathways that regulate cell migration, survival, and proliferation are mediated by the EGFR tyrosine kinase, which is selectively inhibited by gefitinib. Gefitinib can stop the proliferation of cancer cells by blocking this route.

Uses:

Non-small cell lung cancer

Dosage and Administration:

250mg once daily, taken with or without food. The tablet should be swallowed whole with water. Do not crush or chew the tablet.

Side Effects:

·         Rash (acne-like)

·         Diarrhea

·         Fatigue

·         Nausea

·         Vomiting

·         Shortness of breath

·         Bone pain

·         Constipation

·         Loss of appetite

·         Dry skin

·         Cough

Safety Advise:

Liver  

Gefitinib can harm the liver and raise liver enzymes. Regular liver function tests are recommended, particularly for people who already have liver disease. Kindly speak with your healthcare provider.

Kidney  

Regular kidney function tests are recommended, particularly for people who already have renal disease. Kindly speak with your healthcare provider.

Pregnancy  

Gefitinib may be harmful to the developing fetus. During treatment, effective contraception should be used. Kindly speak with your healthcare provider.

Breast Feeding  

Since it is unknown whether erlotinib gets into breast milk, it is not advised during treatment. Kindly speak with your healthcare provider.

Alcohol  

The safety of combining Geftinat 250mg Tablet with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature (15°C to 30°C) in a dry place, away from light and moisture.

How to use this Medication?

This medication should be taken orally with a full glass of water. Observe the medicine label's instructions. It can be taken with or without meals. Take your medication on a regular basis. Avoid taking it more frequently than prescribed. Except as directed by your physician, do not discontinue taking.

Inform your physician, chemist, or other healthcare provider if you have trouble taking the tablets. They can offer you guidance.

 
Consult your pediatrician about this medication's use in kids. Extra caution could be required.

References:

1.     Rawluk J, Waller CF. Gefitinib. Small molecules in oncology. 2018:235-46.

2.     Rahman AM, Korashy HM, Kassem MG. Gefitinib. Profiles of drug substances, excipients and related methodology. 2014 Jan 1;39:239-64.

3.    Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y. Gefitinib or chemotherapy for non–small-cell lung cancer with mutated EGFR. New England journal of medicine. 2010 Jun 24;362(25):2380-8.

Disclaimer:

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Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India