Venclexta 100mg Tablet includes Venetoclax is an oral prescription medicine used to treat certain blood malignancies, such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and, when combined with other medications, acute myeloid leukemia in certain patient populations.

Brand Name: Venclexta

Composition: Venetoclax

Mechanism of Action:

Venetoclax is a specific inhibitor of the anti-apoptotic protein BCL-2, which is overexpressed in several malignancies. By inhibiting BCL-2, it restores the natural process of programmed cell death (apoptosis), which results in the demise of cancer cells.

Uses:

·       Chronic lymphocytic leukaemia

·       Acute myeloid leukaemia

Dosage and Administration:

Venclexta is taken orally once per day, with food. To prevent tumor lysis syndrome (TLS), the dosage is progressively increased over several weeks.

Side Effects:

·       Low white blood cell counts

·       Nausea​

·       Diarrhea​

·       Anemia​

·       Fatigue​

·       Upper respiratory tract infections​

·       Tumor lysis syndrome

Safety Advise:

Lungs  

The safety of Venclexta Tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Venclexta Tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Venclexta Tablet for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Venclexta Tablet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Venclexta Tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep at room temperature (15-30 °C). Store in a dry place away from moisture and sunlight.

How to use this Medication?

Take this medication orally with food and a glass of water. Follow the instructions on your prescription label. Don't cut, crush, or chew this medication. Do not combine with grapefruit juice or consume Seville oranges or starfruit. Take your medications at regular times. Do not take it more frequently than prescribed. Stop taking only if your doctor advises you to.

The pharmacist will provide you with a unique MedGuide along with each prescription and refill. Make sure to read this material thoroughly each time.

References:

1.      Mihalyova J, Jelinek T, Growkova K, Hrdinka M, Simicek M, Hajek R. Venetoclax: A new wave in hematooncology. Experimental hematology. 2018 May 1;61:10-25.

2.      Bose P, Gandhi V, Konopleva M. Pathways and mechanisms of venetoclax resistance. Leukemia & lymphoma. 2017 Sep 2;58(9):2026-39.

3.      Pollyea DA, Amaya M, Strati P, Konopleva MY. Venetoclax for AML: changing the treatment paradigm. Blood advances. 2019 Dec 23;3(24):4326-35.

4.      Deeks ED. Venetoclax: first global approval. Drugs. 2016 Jun;76:979-87.

Disclaimer:

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Marketer details

Name: Abbvie Therapeutics India Pvt Ltd

Address: Level 6 & 7, Prestige Obelisk, 3, Kasturba Rd, Ambedkar Veedhi, Bengaluru, Karnataka 560001

Country of origin: India