Zoladex 10.8mg Injection contains Goserelin acetate, a synthetic hormone that acts as a gonadotropin-releasing hormone (GnRH) analog.

Brand Name: Zoladex

Composition: Goserelin acetate

Mechanism of Action:

Zoladex functions by preventing the pituitary gland from releasing gonadotropins (FSH and LH). As a result, the body produces less sex hormones (oestrogen in women and testosterone in men), which lowers hormone levels.

Uses:

• Prostate Cancer
• Breast Cancer
• Endometriosis
• Uterine Fibroids

Dosage and Administration:

Usually given as a monthly or three-monthly subcutaneous injection, depending on the particular indication and treatment regimen. administered in a therapeutic environment by a medical professional.

Side Effects:

• Hot flashes
• Night sweat
• Weight gain
• Mood change
• Dizziness
• Allergic reactions
• Osteoporosis
• Reduced libido
• Nausea
• Vomiting
• Fever

Safety Advise:

Lungs  

The safety of Zoladex Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Zoladex Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Zoladex Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

  Pregnancy  

Zoladex should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Zoladex while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Zoladex should be kept in the refrigerator between 2°C and 8°C (36°F and 46°F). The formulation may be harmed by freezing, so avoid doing so.

How to use this Medication?

With the help of an implant, this drug gradually delivers hormones into your body. A medical practitioner injects it beneath the skin of the lower belly, just below the navel. Over the course of a few weeks or months, the implant itself will be fully absorbed by the body.

Administer this medication as directed by your doctor, with the 3.6 mg syringe typically injected every 4 weeks and the 10.8 mg syringe every 12 to 13 weeks. Follow the dosing schedule closely, mark your calendar for doses, and do not stop the medication without your doctor's approval.

References:

1.  Moghissi KS, Schlaff WD, Olive DL, Skinner MA, Yin H. Goserelin acetate (Zoladex) with or without hormone replacement therapy for the treatment of endometriosis. Fertility and sterility. 1998 Jun 1;69(6):1056-62.

2.  Asbury RF, Brunetto VL, Lee RB, Reid G, Rocereto TF. Goserelin acetate as treatment for recurrent endometrial carcinoma: a Gynecologic Oncology Group study. American journal of clinical oncology. 2002 Dec 1;25(6):557-60.

3.  Goldspiel BR, Kohler DR. Goserelin acetate implant: a depot luteinizing hormone-releasing hormone analog for advanced prostate cancer. Dicp. 1991 Jul;25(7-8):796-804.

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Country of origin: India