Zyceva 100mg Tablet contains Erlotinib, a medication used in the treatment of certain types of cancer, primarily non-small cell lung cancer and pancreatic cancer. Erlotinib is a targeted treatment that prevents the growth and spread of cancer cells by blocking the function of the epidermal growth factor receptor.

Brand Name: Zyceva

Composition: Erlotinib

Mechanism of Action:

The way erlotinib functions is by inhibiting the EGFR tyrosine kinase, an enzyme that is hyperactive in some types of cancer. Erlotinib lowers the survival and multiplication of cancer cells by blocking this enzyme.

Uses:

• Non-Small Cell Lung Cancer
• Pancreatic Cancer

Dosage and Administration:

Depending on the indication, take 100 mg or 150 mg once daily. It must be taken either two hours after eating or at least one hour before. For efficacy, dosing timing must be consistent.

Side Effects:

·         Rash (acne-like)

·         Diarrhea

·         Fatigue

·         Nausea

·         Vomiting

·         Shortness of breath

·         Bone pain

·         Constipation

·         Loss of appetite

·         Dry skin

·         Cough

Safety Advise:

Liver  

Erlotinib can harm the liver and raise liver enzymes. Regular liver function tests are recommended, particularly for people who already have liver disease. Kindly speak with your healthcare provider.

Kidney  

Regular kidney function tests are recommended, particularly for people who already have renal disease. Kindly speak with your healthcare provider.

Pregnancy  

Erlotinib may be harmful to the developing fetus. During treatment, effective contraception should be used. Kindly speak with your healthcare provider.

Breast Feeding  

Since it is unknown whether erlotinib gets into breast milk, it is not advised during treatment. Kindly speak with your healthcare provider.

Alcohol  

The safety of combining Zyceva 100mg Tablet with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature, away from heat and moisture.

How to use this Medication?

On an empty stomach, take erlotinib pills orally with a glass of water at least one hour before or two hours after meals. Steer clear of grapefruit juice. Observe the instructions on your prescription, take it as directed, and don't stop taking it or change the dosage without first consulting your doctor.

Consult your pediatrician about this medication's use in kids. Extra caution could be required.

References:

1.      Bareschino MA, Schettino C, Troiani T, Martinelli E, Morgillo F, Ciardiello F. Erlotinib in cancer treatment. Annals of oncology. 2007 Jun 1;18:vi35-41.

2.      Tang PA, Tsao MS, Moore MJ. A review of erlotinib and its clinical use. Expert opinion on pharmacotherapy. 2006 Feb 1;7(2):177-93.

3.   Tsao MS, Sakurada A, Cutz JC, Zhu CQ, Kamel-Reid S, Squire J, Lorimer I, Zhang T, Liu N, Daneshmand M, Marrano P. Erlotinib in lung cancer—molecular and clinical predictors of outcome. New England Journal of Medicine. 2005 Jul 14;353(2):133-44.

4.   Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, van Kooten M. Erlotinib in previously treated non–small-cell lung cancer. New England journal of medicine. 2005 Jul 14;353(2):123-32.

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Marketer details

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Country of origin: India