Pangraf 1mg Capsule contains Tacrolimus, an immunosuppressive drug primarily used to prevent organ transplant rejection and to treat autoimmune diseases. Tacrolimus functions by suppressing T-lymphocyte activity, which is in charge of immunological responses that can result in autoimmune reactions or the rejection of donated organs.

Brand Name: Pangraf

Composition: Tacrolimus

Mechanism of Action:

Tacrolimus suppresses the enzyme calcineurin, which is implicated in immune system T-cell activation. Tacrolimus prevents organ rejection by lowering the immune response through blocking this route.

Uses:

Prevention of organ rejection in transplant patients (kidney, liver, or heart transplants)

Dosage and Administration:

The capsule should be swallowed whole with water, not crushed or chewed. Usually taken once daily in the morning on an empty stomach.

Side Effects:

• Tremors
• Rash
• Headache
• Nausea
• Vomiting
• Dizziness
• Fatigue
• Diarrhea
• High blood pressure
• Kidney dysfunction
• High blood sugar levels

Safety Advise:

Kidney  

Monitor kidney function regularly, as tacrolimus can cause nephrotoxicity. Kindly speak with your healthcare provider.

Liver  

Monitor liver function regularly, as tacrolimus can cause liver impairement. Kindly speak with your healthcare provider.

Pregnancy  

Pangraf should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Pangraf 1mg Capsule while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Pangraf 1mg Capsule should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Store Pangraf capsules at a temperature between 15°C and 30°C (59°F to 86°F). Keep the capsules in the original packaging to protect them from light and moisture. Keep out of reach of children.

How to use this Medication?

Tacrolimus comes in various forms and should be taken as directed, with immediate-release capsules taken twice daily and extended-release forms taken once daily on an empty stomach. Always take tacrolimus at the same time each day as directed by your doctor.

Do not split, chew, or crush the extended-release capsules; instead, swallow them whole with water. The immediate-release capsules should not be opened or crushed.

References:

1.      Hooks MA. Tacrolimus, a new immunosuppressant—a review of the literature. Annals of Pharmacotherapy. 1994 Apr;28(4):501-11.

2.      Kelly PA, Burckart GJ, Venkataramanan R. Tacrolimus: a new immunosuppressive agent. American journal of health-system pharmacy. 1995 Jul 1;52(14):1521-35.

3.   Venkataramanan R, Swaminathan A, Prasad T, Jain A, Zuckerman S, Warty V, McMichael J, Lever J, Burckart G, Starzl T. Clinical pharmacokinetics of tacrolimus. Clinical pharmacokinetics. 1995 Dec;29:404-30.

4.   Peters DH, Fitton A, Plosker GL, Faulds D. Tacrolimus: a review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs. 1993 Oct;46:746-94.

5.   Spencer CM, Goa KL, Gillis JC. Tacrolimus: an update of its pharmacology and clinical efficacy in the management of organ transplantation. Drugs. 1997 Dec;54(6):925-75.

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Marketer details

Name: Panacea Biotec Pharma Ltd

Address: "Panacea Biotec Pharma Ltd B-1,Extn/A-27,Mohan Co-operative Industrial Estate Mathura Road, New Delhi-110044"

Country of origin: India