Enbrel 50mg Injection

Enbrel 50mg Injection contains Etanercept, a biologic medication used primarily in the treatment of autoimmune diseases. It is an inhibitor of tumor necrosis factor (TNF) that aids in immune response modulation and inflammation reduction.

Brand Name: Enbrel

Composition: Etanercept

Mechanism of Action:

TNF, a pro-inflammatory cytokine implicated in systemic inflammation, is bound by etanercept, a soluble TNF receptor. Intacept helps to lower inflammation and the immune system's overall response by blocking TNF activity, which lessens the symptoms of autoimmune disorders.

Uses:

• Rheumatoid Arthritis
• Psoriatic Arthritis
• Ankylosing Spondylitis
• Crohn's Disease
• Ulcerative Colitis

Dosage and Administration:

The disease being treated and the patient's reaction determine the amount and frequency of administration. Usually, it can be injected subcutaneously, with maintenance doses given at predetermined intervals after the initial dose.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Dizziness

·       Fever

·       Rash

·       Headache

·       Allergic reactions

·       Seizures

·       Thrombocytosis

Safety Advise:

Kidney  

Dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease. Kindly speak with your healthcare provider.

Pregnancy  

Use Enbrel during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Driving  

Your ability to drive may be impacted by adverse effects from Enbrel Injection. Kindly speak with your healthcare provider.

Storage:

Store Enbrel Injection in the refrigerator (2-8°C) and protect it from light. It should not be frozen.

How to use this medication?

The drug is administered subcutaneously. You'll learn how to prepare and administer it. Follow the instructions on the medicine label. Until your care team instructs you to stop, continue taking it.

Make careful to remove the outer needle cover from the pen before administering the dosage. 

It's crucial to store used syringes and needles in a designated sharps container. Keep them out of the garbage can. Get a sharps container by calling your care team or pharmacist if you don't already have one.

References:

1.      Jarvis B, Faulds D. Etanercept: a review of its use in rheumatoid arthritis. Drugs. 1999 Jun;57:945-66.

2.      Ducharme E, Weinberg JM. Etanercept. Expert Opinion on Biological Therapy. 2008 Apr 1;8(4):491-502.

3.      Goffe B, Cather JC. Etanercept: an overview. Journal of the American Academy of Dermatology. 2003 Aug 1;49(2):105-11.

4.      Zhao S, Mysler E, Moots RJ. Etanercept for the treatment of rheumatoid arthritis. Immunotherapy. 2018 Feb 27;10(6):433-45.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Pfizer Ltd

Address: The Capital, 1802, 18th Floor, Plot No. C-70, ‘G’ Block, Bandra Kurla Complex, Bandra East, Mumbai – 400051.

Country of origin: India

Frequently Asked Questions (FAQs):

1. What is Enbrel 50mg Injection?

Enbrel 50mg contains Etanercept, a biological disease-modifying antirheumatic drug (DMARD). It may be prescribed to potentially manage severe autoimmune joint and skin conditions, requiring strict adherence to a specialist's care plan.

2. How may Enbrel work?

It is believed to act as a Tumor Necrosis Factor (TNF) blocker. By potentially inhibiting TNF, a protein involved in inflammation, it may help reduce joint pain, swelling, and skin lesions.

3. What conditions may it be prescribed for?

It may be considered for moderate-to-severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis, based on a doctor's diagnosis.

4. How is Enbrel 50mg administered?

It is administered as a once-weekly subcutaneous injection. If self-administering, you must strictly adhere to the injection technique and hygiene protocols taught by your healthcare provider.

5. What are the possible side effects?

Patients may potentially experience injection site reactions (redness, itching), upper respiratory infections, headache, or rash.

6. Does it increase the risk of serious infections?

Yes, because it suppresses the immune system, patients may potentially be at a higher risk for serious infections like tuberculosis or fungal infections. Adhere strictly to your doctor's instructions on seeking care for fevers.

7. Is TB screening necessary before starting?

Yes, doctors mandate screening for latent tuberculosis prior to initiating therapy. You must adhere to all pre-treatment testing guidelines.

8. Can it be used if I have heart failure?

It may potentially worsen heart failure symptoms. Careful medical assessment is required, and you must inform your doctor of any cardiac history.

9. Are there neurological risks?

Rarely, TNF blockers may potentially be associated with demyelinating diseases like multiple sclerosis. Routine adherence to neurological monitoring may be advised by your physician.

10. How should it be stored?

It must typically be kept in the refrigerator (2°C–8°C) and protected from light. Adhere to your pharmacist's storage guidelines carefully.

11. How long does it take to see potential results?

Some patients may potentially notice improvements within a few weeks, but it may take several months. Continued adherence to the weekly injection schedule is required.

12. Is Enbrel a prescription medicine?

Yes, it is available by prescription only and must be used under a specialist's supervision.

Medical Disclaimer:

Enbrel 50mg Injection is a prescription-only medicine and must be used strictly under the supervision and guidance of a qualified healthcare professional. Do not self-medicate, alter the dosage, or discontinue use without consulting your doctor. The information provided here is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Individual results, benefits, and risks may vary. Always consult your physician before starting, changing, or stopping any medication.