Oxitan 50mg Injection

Oxitan 50mg Injection contains Oxaliplatin as its active ingredient. The chemotherapy drug that is mainly used to treat colorectal cancer is oxaliplatin. It is one of the group of medications called platinum-based antineoplastic medicines.

Brand Name: Oxitan

Composition: Oxaliplatin

Mechanism of Action:

Following its metabolism in the body, oxaliplatin produces reactive platinum molecules. These substances attach themselves to DNA and cause DNA strands to cross-link, which prevents cancer cells from replicating and transcriptionally using DNA. This eventually results in apoptosis, or cell death, especially in malignant cells that divide quickly. Oxaliplatin is effective against some cancer cells that are resistant to other medicines like cisplatin and carboplatin, but it has a different toxicity profile than other platinum-based medications.

Uses:

·       Colorectal Cancer

Dosage and Administration:

Usually given once every two or three weeks as part of a treatment cycle, the standard dosage of Oxaliplatin is based on body surface area (mg/m2) and is used in conjunction with other chemotherapy medicines such as leucovorin and fluorouracil. Over two to six hours, the medication is gradually injected.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Rash

·       Headache

·       Weakness

·       Fever

·       Difficulty breathing

·       Allergic reactions

·       Mouth sores

·       Constipation

Safety Advise:

Kidney  

Dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease, as oxalipatin can cause elevated liver enzymes. Kindly speak with your healthcare provider.

Pregnancy  

Use oxalipatin during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Alcohol  

The safety of using Oxitan 50mg Injection with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store in a refrigerator (2-8°C). Protect from light. Do not freeze.

How to use this medication?

Oxaliplatin is a liquid solution that is administered intravenously. A physician or nurse administers oxaliplatin. Typically, it is administered once every 14 days.

Request a copy of the manufacturer's information for the patient from your physician or pharmacist.

References:

1.   Raymond E, Chaney SG, Taamma A, Cvitkovic E. Oxaliplatin: a review of preclinical and clinical studies. Annals of Oncology. 1998 Oct 1;9(10):1053-71.

2.   Graham J, Muhsin M, Kirkpatrick P. Oxaliplatin. Nature reviews Drug discovery. 2004 Jan;3(1):11-2.

3.   Raymond E, Faivre S, Chaney S, Woynarowski J, Cvitkovic E. Cellular and molecular pharmacology of oxaliplatin. Molecular cancer therapeutics. 2002 Jan 1;1(3):227-35.

4.   Misset JL, Bleiberg H, Sutherland W, Bekradda M, Cvitkovic E. Oxaliplatin clinical activity: a review. Critical reviews in oncology/hematology. 2000 Aug 1;35(2):75-93.

Disclaimer:

The main goal of Apothecare is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details:

Name: Fresenius Kabi India Pvt Ltd
Address: Fresenius Kabi AG​ , Else-Kröner-Straße 1 ​ , 61352 Bad Homburg , Germany
Country of origin: India

1.     What is Oxitan 50 mg Injection used for?
Oxitan 50 mg Injection is an anticancer medicine commonly used to treat colorectal and certain other cancers. It should be administered only under your doctor's guidance.

2.     How is Oxitan 50 mg Injection given?
This injection is given as an intravenous infusion by a qualified healthcare professional in a hospital or clinic. Follow your doctor's treatment schedule carefully.

3.     What are the common side effects of Oxitan 50 mg Injection?
Common side effects include nausea, vomiting, tiredness, numbness or tingling in the hands and feet, and low blood cell counts. Inform your doctor if any side effects become severe or persistent.

4.     Are there any special precautions while taking Oxitan 50 mg Injection?
Avoid exposure to cold temperatures or cold drinks immediately after treatment, as they may worsen nerve-related side effects. Consult your doctor for proper precautions during therapy.

5.     Will I need monitoring during treatment?
Yes, regular blood tests and medical check-ups may be required to monitor your response and detect any side effects early. Attend all follow-up visits as advised by your doctor.