Themiset 250mcg Injection – Uses, Price & Nausea Prevention

Themiset 250mcg Injection 

Themiset Injection 5 ml contains Palonosetron is an antiemetic drug used to stop nausea and vomiting brought on by radiation, chemotherapy, or surgery. Palonosetron is frequently used in supportive care for cancer patients and is a member of the class of selective serotonin 5-HT3 receptor antagonists. During cancer therapy, it enhances the comfort and quality of life of the patient.

Brand Name: Themiset

Composition: Palonosetron Hydrochloride

Mechanism of Action:

A specific antagonist of the 5-hydroxytryptamine-3 (5-HT3) receptor is palonosetron. Chemotherapy and radiation therapy can cause the small intestine's enterochromaffin cells to produce serotonin, which activates 5-HT3 receptors and causes nausea and vomiting. Palonosetron prevents chemotherapy-induced nausea and vomiting (CINV) by blocking serotonin binding at these receptors, which are found both peripherally in the gastrointestinal tract and centrally in the chemoreceptor trigger zone (CTZ). 

Uses of Themiset Injection:

• Preventing chemotherapy-induced nausea and vomiting

• Preventing postoperative nausea and vomiting

• Preventing nausea and vomiting brought on by radiation therapy

Dosage and Administration:

The standard recommended dose is 250 mcg intravenously, administered approximately 30 minutes before chemotherapy. The medicine should be given only under the supervision of a healthcare professional.

Side Effects of Themiset Injection:

• Headache
• Constipation
• Diarrhea
• Dizziness
• Injection site pain
• Fatigue

Safety Advice:

Lungs  

The safety of Themiset Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Themiset Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney                               

The safety of Themiset Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy                         

Themiset should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Themiset while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Store below 30°C in a dry place away from direct sunlight and moisture. Keep out of reach of children.

How to use this Medication?

A medical practitioner will inject Themiset Injection intravenously before to chemotherapy, radiation, or surgery. Don't take this medication on your own. Pay close attention to every instruction your doctor gives you. Tell your doctor about all other medications you take, particularly those that influence your heart rhythm or antidepressants.

FAQs about Themiset Injection:

What is Themiset 250mcg Injection used for?

It is used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.

How does Themiset Injection work?

It contains Palonosetron, which blocks serotonin receptors responsible for triggering nausea and vomiting.

What is the price of Themiset Injection in India?

The price generally ranges between ₹150 to ₹300 depending on pharmacy discounts and availability.

Is Themiset used for chemotherapy patients?

Yes, it is commonly used to prevent chemotherapy-induced nausea and vomiting (CINV).

Can Themiset be used after surgery?

Yes, it is also used to prevent post-operative nausea and vomiting (PONV).

What are the common side effects of Themiset Injection?

Common side effects may include headache, constipation, dizziness, and fatigue.

Is Themiset a strong anti-nausea medicine?

Yes, Palonosetron is a long-acting antiemetic widely used in cancer care.

Can Themiset Injection be self-administered?

No, it should be administered by a healthcare professional in a hospital or clinical setting.

Reference:

1. Aapro M, Grunberg SM, Manikhas GM, et al. A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. Ann Oncol. 2006;17(9):1441-1449.
2. Rojas C, Slusher BS. Pharmacological mechanisms of 5-HT3 and tachykinin NK1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting. Eur J Pharmacol. 2012;684(1-3):1-7.

Disclaimer:

The main goal of Apothecare is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Themis Medicare Limited
Address: Sector 6A, Plot No. 16,17 & 18, IIE, Sidcul, Haridwar-249403, Uttarakhand.
Country of Origin: India