Leucolive 50mg Injection – Uses, Price & Leucovorin Calcium for Methotrexate Rescue

Leucolive 50mg Injection contains Leucovorin Calcium is used to stop the negative effects of the anticancer drug methotrexate. Additionally, it is used to treat methotrexate overdose. 

Brand Name: Leucolive

Composition: Leucovorin Calcium 50mg

Mechanism of Action:

Leucovorin is one active form of folic acid. It avoids the metabolic block caused by methotrexate, which prevents the production of nucleotides required for DNA synthesis and repair by inhibiting the enzyme dihydrofolate reductase. This lessens the negative effects of methotrexate on healthy cells.

Uses of Leucolive 50mg Injection: 

• Methotrexate Rescue

Side Effects of Leucolive 50mg Injection:

• Severe allergic reactions
• Nausea
• Vomiting
• Swelling
• Redness
• Diarrhea
• Dizziness
• Skin rash

Dosage and Administration:

Depending on the therapeutic circumstance, leucorin is usually given intravenously. The chemotherapy regimen and the ailment being treated determine the dosage and timing of treatment.

Contraindications/Warnings: 

Leucovorin calcium is contraindicated for the treatment of pernicious anemia and other megaloblastic anemias due to vitamin B12 deficiency, as it may produce a hematologic remission while allowing progressive neurological damage to continue unrecognized. When used for methotrexate rescue, the timing and dose of leucovorin must strictly follow the treating physician's protocol, as delayed or inadequate administration can result in severe, potentially fatal methotrexate toxicity. Leucovorin should not be administered intrathecally. Leucovorin can increase the toxicity of 5-fluorouracil when the two are combined; patients on this combination require close monitoring, particularly of gastrointestinal side effects.

Safety Advise: 

Lungs  

The safety of Leucolive Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Leucolive Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Leucolive Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Leucolive should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Leucolive while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Storage:

Storage in 2-8 °C, do not freeze. Keep away from children and place away from sun light.

How to use this Medication?

As directed by your physician, this drug is injected into a vein or muscle once daily or usually every six hours. It should not be injected into the spine.

Your medical condition and reaction to therapy will determine the dosage. Use it frequently for best results. If using at home, make sure you follow your doctor's preparation and usage guidelines and look for any particles or discolouration before using. Learn how to properly store and dispose of medical items as well.

Contact an emergency department or poison control center right away if you believe you have taken too much of this medication.

Frequently Asked Questions (FAQs):

1. What is Leucolive 50mg Injection used for?

It is mainly used for methotrexate rescue and management of methotrexate toxicity or overdose.

2. How does Leucolive work?

Leucovorin provides reduced folate to healthy cells, helping protect them from the effects of folate-blocking medicines.

3. What is leucovorin rescue?

It is the use of Leucovorin after high-dose Methotrexate to help reduce toxicity to healthy cells.

4. Is Leucolive chemotherapy?

No. Leucolive is Leucovorin Calcium (folinic acid) and is commonly used as supportive or rescue therapy.

5. Is Leucolive used with 5-FU?

Yes. Leucovorin can also be combined with 5-fluorouracil (5-FU) in certain cancer-treatment regimens.

6. How is Leucolive administered?

It is administered by a healthcare professional according to the prescribed treatment or rescue protocol.

Disclaimer:

The main goal of Apothecare Specialities Pvt Ltd is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Specialities Pvt Ltd, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

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Country of origin: India